Title:Steric-on-Demand Phosphine Ligands for Tackling Highly Steric-Congested Cross-Coupling Processes
Speaker: Prof. Kuang Fuer
Time: April 07, 9:00
Venue:Conference Room, 4th Floor, Yifu Engineering Building, School of Chemistry and Chemical Engineering
[Abstract]
Transition metal-catalyzed cross-coupling protocol has emerged as a highly versatile way for assembling creative and useful molecules.1 By proficiently manipulating the phosphine ligand chassis and thus adjusting the geometry of associated metal complexes, a diverse range of these cutting-edge processes has been successfully established as valuable synthetic schemes. Cross-coupling reactions leading to the generation of C(Ar)-C(Ar’) biaryl axis in highly steric-hindered environment have presented significant challenges. The use of exceptionally bulky ligands can impede the approach of the substrate to the metal center, potentially diminishing the efficiency of substrate binding. Yet, these bulky ligands can facilitate the reductive elimination process, creating a dilemma in the selection of appropriate phosphine ligands for tackling extremely steric-congested cross-coupling reactions.
Announced by School of Chemistry and Chemical Engineering
